種を通して保存された昆虫ストレス応答機構の解明
メンバー： 天竺桂弘子
分野： 動物生命科学、境界農学、ゲノム科学
所属： 農学研究院
キーワード： 比較ゲノム学、昆虫、酸化ストレス応答、ヒト遺伝子ホモログ
ウェブサイト：
研究概要
昆虫は地球上で最も繁栄している種です。研究室ではこれまでに公共データベースや大規模遺伝子発現解析から、昆虫にはヒトと共通する遺伝子が数多く存在していることを明らかにしています。昆虫は環境に素早く適応できる分子機構を持ちますが、この仕組みはヒトをはじめとする哺乳類と多くの部分で共通します。これらの遺伝子の機能を明らかにすることができれば、昆虫がヒトと共通する遺伝子を利用してストレスを上手に回避する仕組みを解明することが出来ます。
主要論文・参考事項
(1) Nojima Y, Ito K, Ono H, Nakazato T, Bono H, Yokoyama T, Sato R, Suetsugu Y, Nakamura Y, Yamamoto K, Satoh J, Tabunoki H*, Fugo H.: Superoxide Dismutases, SOD1 and SOD2, Play a Distinct Role in the Fat Body during Pupation in Silkworm Bombyx mori. PLoS One. (2015) 10, e0116007
(2) Uemura N, Tabunoki H*, Suzuki T, Ishikawa K, Nojima Y, Katsuma S, Sato R, Satoh J. : Production of wild-type and mutant-type human DAP12 proteins by Bombyx mori nucleopolyhedrovirus vector. Bioscience, Biotechnology, and Biochemistry (2014) 78, 71-74
(3) Tabunoki H*, Ono H, Ode H, Ishikawa K, Kawana N, Banno Y, Shimada T, Nakamura Y, Yamamoto K, Satoh J, Bono H.: Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease. PLoS One (2013) 8, e69130
(4) Tabunoki H*, Ode H, Banno Y, Katsuma S, Shimada T,Mita K , Yamamoto K, Sato R, Ishii-Nozawa R, Satoh J. : BmDJ-1 is a Key Regulator of Oxidative Modification in the Development of the Silkworm, Bombyx mori. PLOS ONE (2011) 6(3):e17683.
お問い合わせ先
東京農工大学・先端産学連携研究推進センター
urac[at]ml.tuat.ac.jp（[at]を@に変換してください）
Elucidation of molecular mechanisms for resistance to oxidative stress tolerance cncerved across the insect species
Research members： Hiroko Tabunoki PhD.
Research fields： Animal life science, Boundary agriculture, Genome science
Departments： Institute of Agriculture
Keywords： comparative genomics, insects, oxidative-stress response, human homolog
Web site：
Summary
Stress can arise from several factors. Furthermore, fluctuating or changing environmental conditions can have physiological effects on development, aging, growth, longevity, survival, and reproduction.
Insects are exposed to a variety of environmental stresses. Here is a number of causative factors of stress, such as: sunlight (ultra violet radiation), temperature, humidity (especially dry conditions), starvation, external hazards, metamorphosis in holometabolous insects, insecticides, and so on. Importantly, insects can rapidly adapt through physiological responses to changes in their environment.
For the present study, the genomic information of various organisms was readily accessible
on public databases. We utilized the genomic information to identify genes that are conserved across species and species-specific genes.
As a result, we were able to identify the physiological machinery conserved across species and the species-specific function of genes.
Reference articles and patents
(1) Nojima Y, Ito K, Ono H, Nakazato T, Bono H, Yokoyama T, Sato R, Suetsugu Y, Nakamura Y, Yamamoto K, Satoh J, Tabunoki H*, Fugo H.: Superoxide Dismutases, SOD1 and SOD2, Play a Distinct Role in the Fat Body during Pupation in Silkworm Bombyx mori. PLoS One. (2015) 10, e0116007
(2) Uemura N, Tabunoki H*, Suzuki T, Ishikawa K, Nojima Y, Katsuma S, Sato R, Satoh J. : Production of wild-type and mutant-type human DAP12 proteins by Bombyx mori nucleopolyhedrovirus vector. Bioscience, Biotechnology, and Biochemistry (2014) 78, 71-74
(3) Tabunoki H*, Ono H, Ode H, Ishikawa K, Kawana N, Banno Y, Shimada T, Nakamura Y, Yamamoto K, Satoh J, Bono H.: Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease. PLoS One (2013) 8, e69130
(4) Tabunoki H*, Ode H, Banno Y, Katsuma S, Shimada T,Mita K , Yamamoto K, Sato R, Ishii-Nozawa R, Satoh J. : BmDJ-1 is a Key Regulator of Oxidative Modification in the Development of the Silkworm, Bombyx mori. PLOS ONE (2011) 6(3):e17683.
Contact
University Research Administration Center(URAC),
Tokyo University of Agriculture andTechnology
urac[at]ml.tuat.ac.jp
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