マリンカルチャーコレクションからの有用物質探索、およびグリーンプロセスへの応用
メンバー: 田中剛、前田義昌、武藤正記
分野: プロセス・化学工学、生物科学
所属: 工学研究院
キーワード: バイオ燃料・生理活性物質生産、創薬探索、排水処理、微細藻類
ウェブサイト:
研究概要

海洋は地球の表面積の約7割、平均深度3800 mを有すると同時に、高温、低温、高圧など陸上には無い特殊環境が存在します。そのため、多様な環境に適応するための能力を持った多種多様な生物が存在します。当研究室では、微細藻類、光合成細菌などの海洋光合成微生物に着目し、カルチャーコレクションを構築すると共に、様々な有用物質生産株のスクリーニングを行っています。スクリーニングしてきた株を培養し、抽出・精製を行うことにより目的の物質を入手することが出来ます。これまで抗酸化作用を示すアスタキサンチン、抗菌物質、農薬、医薬品、多糖、水素、サプリメントに応用できるDHA、EPA、バイオ燃料の原料となる脂肪族炭化水素やトリグリセリドなどの様々な有用物質を生産する株をスクリーニングしてきました。さらに、遺伝子工学や微生物工学の手法を利用することにより、実用化に向けた生産方法についても検討を進めています。
主要論文・参考事項
1.R. Sato, Y. Maeda, T. Yoshino and T. Tanaka & M. Matsumoto "Seasonal variation of biomass and oil production of the oleaginous diatom Fistulifera sp. in outdoor vertical bubble column and raceway-type bioreactors" J. Biosci. Bioeng., Accepted (2013)
2.Y. Liang, Y. Maeda, Y. Sunaga, M. Muto, M. Matsumoto, T. Yoshino & T. Tanaka “Biosynthesis of polyunsaturated fatty acids in the oleaginous marine diatom Fistulifera sp. strain JPCC DA0580” Mar. Drugs, Accepted (2013)
3.A. Satoh, K. Ichii, M. Matsumoto, C. Kubota, M. Nemoto, M. Tanaka, T. Yoshino, T. Matsunaga & T. Tanaka "A process design and productivity evaluation for oil productionby indoor mass cultivation of a marine diatom, Fistulifera sp. JPCC DA0580" Biores. Technol., 137. 132-138 (2013)
4.A. Arakaki, D. Iwama, Y. Liang, N. Murakami, M. Ishikura, T. Tanaka & T. Matsunaga “Glycosylceramides from marine green microalga Tetraselmis sp.” Phytochemistry, 85. 107-114 (2013)
お問い合わせ先
東京農工大学・先端産学連携研究推進センター
urac[at]ml.tuat.ac.jp([at]を@に変換してください)
Exploration of useful compounds from marine culture collection and the application to Green Process
Research members: Dr. Tsuyoshi Tanaka, Dr. Yoshiaki Maeda, Dr. Masaki Muto
Research fields: Process/Chemical engineering, Biological Science
Departments: Institute of Engineering
Keywords: biofuel, physiologically active substance, search for creating medicines, wastewater treatment, microalga
Web site:
Summary

Marine photosynthetic microorganisms are the largest primary producers of biomass in the marine environment. Their metabolic functions have developed during the evolutionary process for the adaptation of these microorganisms to diversified marine environments. With the development of marine biotechnology, photosynthetic microorganisms from unique and extreme marine environments are attracting attention as new biological resources. We have constructed our original marine microbial culture collection, called No-Ko culture collection, mainly including photosynthetic microorganisms. Among the NKCC, useful strains have been selected for the production of useful materials, such as a UV-A absorbing substance, a plant growth regulator, carotenoids, antimicrobial substance, drugs, polysaccharides, biofuels etc.. We have also developed genetic engineered marine microorganisms for production of useful compounds.
Reference articles and patents
1.R. Sato, Y. Maeda, T. Yoshino and T. Tanaka & M. Matsumoto "Seasonal variation of biomass and oil production of the oleaginous diatom Fistulifera sp. in outdoor vertical bubble column and raceway-type bioreactors" J. Biosci. Bioeng., Accepted (2013)
2.Y. Liang, Y. Maeda, Y. Sunaga, M. Muto, M. Matsumoto, T. Yoshino & T. Tanaka “Biosynthesis of polyunsaturated fatty acids in the oleaginous marine diatom Fistulifera sp. strain JPCC DA0580” Mar. Drugs, Accepted (2013)
3.A. Satoh, K. Ichii, M. Matsumoto, C. Kubota, M. Nemoto, M. Tanaka, T. Yoshino, T. Matsunaga & T. Tanaka "A process design and productivity evaluation for oil productionby indoor mass cultivation of a marine diatom, Fistulifera sp. JPCC DA0580" Biores. Technol., 137. 132-138 (2013)
4.A. Arakaki, D. Iwama, Y. Liang, N. Murakami, M. Ishikura, T. Tanaka & T. Matsunaga “Glycosylceramides from marine green microalga Tetraselmis sp.” Phytochemistry, 85. 107-114 (2013)
Contact
University Research Administration Center(URAC),
Tokyo University of Agriculture andTechnology
urac[at]ml.tuat.ac.jp
(Please replace [at] with @.)