ヒトと動物に共通する疾患「アレルギー」を克服する
研究概要
イヌやネコなどの伴侶動物は、ヒトと同様アレルギー性疾患を自然発症する。我々は、伴侶動物におけるアレルギー性疾患の病態を解析し、新しい診断法や治療法を開発するための研究を行っている。また、東京農工大学動物医療センターに来院した症例を対象として、新規診断・治療法の有効性を評価している。本研究は、成長著しい伴侶動物の獣医療に直接還元できるだけではなく、トランスレーショナルリサーチとして医学領域にも応用可能な知見を提供することが可能である。
具体的には現在下記の研究を行っている。
（１）消化器型食物アレルギーに関する研究
（２）アナフィラキシー発症メカニズムに関する研究
（３）概日リズムを基盤とするアレルギー病態制御メカニズムの解析
主要論文・参考事項
(1) Ohmori K, Minamide K, Goto S, Nagai M, Shirai J, Oku K. Time-of-day-dependent variations of scratching behavior and transepidermal water loss in mice that developed atopic dermatitis. J. Vet. Med. Sci. 76(11):1501-1504, 2014.
(2) Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H. Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells. Vet. J. 196(3):402-407, 2013.
(3) Ohmori K, Tanaka A, Makita Y, Takai M, Yoshinari Y, Matsuda H. Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus. Vet. Derm. 21(5): 477-483, 2010.
(4) Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J. Immunol. 182(5): 2835-41, 2009.
お問い合わせ先
東京農工大学・先端産学連携研究推進センター
urac[at]ml.tuat.ac.jp（[at]を@に変換してください）
Development of effective diagnostic and therapeutic options for allergic disorders in companion animals
Research members： Dr. Keitaro Ohmori
Research fields： Animal life science
Departments： Institute of Agriculture
Keywords： Dog, Cat, Allergy,Animal model
Web site：
Summary
Companion animals, including dogs and cats, spontaneously develop allergic disorders, like humans do. We analyze pathogenesis of allergic diseases in dogs and cats to develop effective diagnostic and therapeutic options. In addition, we evaluate novel diagnostic and therapeutic methods or agents for allergic diseases by using clinical cases that were referred to Tokyo University of Agriculture and Technology Animal Medical Center. The findings in our study can be applied to not only veterinary medicine but also human medicine as a translational research.
Ongoing projects are as follows:
(1) Gastrointestinal food allergy
(2) Anaphylaxis
(3) Analysis for mechanisms that regulate allergic inflammation based on circadian rhythms
Reference articles and patents
(1) Ohmori K, Minamide K, Goto S, Nagai M, Shirai J, Oku K. Time-of-day-dependent variations of scratching behavior and transepidermal water loss in mice that developed atopic dermatitis. J. Vet. Med. Sci. 76(11):1501-1504, 2014.
(2) Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H. Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells. Vet. J. 196(3):402-407, 2013.
(3) Ohmori K, Tanaka A, Makita Y, Takai M, Yoshinari Y, Matsuda H. Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus. Vet. Derm. 21(5): 477-483, 2010.
(4) Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J. Immunol. 182(5): 2835-41, 2009.
Contact
University Research Administration Center(URAC),
Tokyo University of Agriculture andTechnology
urac[at]ml.tuat.ac.jp
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