Differentiation and the mechanism of organogenesis of stem cells
Research members： Katsuhiko Arai PhD.
Research fields： Animal life science, Basic medicine
Departments： Scleroprotein and Leather Research Institute
Keywords： stem cell, tendon, mesenchyme, collagen, tubulogenesis,
Web site：
Summary
In the process of differentiation of stem cells into tenocytes, osteocytes, neuron and renal tubules, the mechanism of morphogenesis of specific organ structures is investigated. In addition, we study the properties of extracellular matrix proteins in Cnidaria.
1) Development of the method for tenogenic induction of equine bone marrow -derived mesenchymal stem cells.
2) Effects of drugs on experimental wound healing of injured tendon in rabbit.
3) Regulation of tubulogenesis of canine renal tubule cells.
4) Effects of extracellular matrix on neuronal differentiation.
5) Study on immunological similarity between mammalian and cnidarian mucin.
6) Characterization of cell adhesion-inhibitory protein derived from Cnidaria.
Reference articles and patents
1) Miyabara S, Yuda Y,, Kasashima Y, Kuwano A and Arai K. Regulation of tenomodulin expression via Wnt/β-catenin signaling in equine bone marrow-derived mesenchymal stem cells. J. Equine. Sci, in press, 2014.
2) Yuda,Y, Kasashima Y, Kuwano A, Sato K, Hattori S and Arai K.:Active Hyaluronidase 2 Expression in the Granulation Tissue Formed in the Healing Process of Equine Superficial Digital Flexor Tendonitis. J. Vet Med. Sci., 75(2):219－223, 2013.
3) Arai K, Nagashima Y, Takemoto T and Nishiyama T. Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells. Cell Struct Funct. 33:203-210 (2008)
4) Muguruma M, Arai K, Moto M, Nishimura J, Dewa Y, and Mitsumori K. Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice. Arch Toxicol. 82:749-753 (2008)
5) 細胞接着阻害活性を有するクラゲ抽出画分（特願2008－182284）
Contact
University Research Administration Center(URAC),
Tokyo University of Agriculture andTechnology
urac[at]ml.tuat.ac.jp
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